by The 2026 NFL postseason has reached its most electric stage, and the “Toxic Table” is firing on all cylinders. As the Divisional Round approaches, the Pat McAfee Show Divisional Round picks have become the talk of the sports world, blending high-energy analysis with the unfiltered perspective only Pat and the boys can provide. With a slate featuring massive matchups like the Bills at Mile High and a gritty NFC West battle in Seattle, the crew took to the airwaves this Friday to lock in their predictions for what many are calling the most unpredictable weekend in playoff history.
Buffalo Bills at Denver Broncos: Clash at Mile High
Kicking off the weekend, the crew dove into the AFC showdown between the buffalo Bills and the top-seeded Denver Broncos. During the segment on Pat McAfee Show Divisional Round picks, AJ Hawk emphasized the “altitude factor” in Denver, noting that Josh Allen’s power-run game will be tested against the Broncos’ rested defense. While Tone Digs and Ty Schmit were split on the outcome, the consensus leaned toward the Broncos holding court at home, cited primarily by Denver’s dominant regular-season defensive performance and the advantage of coming off a first-round bye.
San Francisco 49ers at Seattle Seahawks: The NFC West Trilogy
The conversation heated up when the focus shifted to the Pacific Northwest for a third meeting between the 49ers and the Seahawks. When discussing the Pat McAfee Show Divisional Round picks, Pat himself highlighted the devastating loss of George Kittle for San Francisco, suggesting that Brock Purdy might struggle without his premier security blanket. Despite the Seahawks being favored by a touchdown, the “Toxic Table” debated whether the 49ers’ “bully ball” could still prevail in a hostile Lumen Field environment, ultimately split on whether the Seahawks’ No. 1 scoring defense would be too much for a depleted Niners roster.
Houston Texans at New England Patriots: The Upset Alert
Perhaps the most surprising part of the afternoon came when the boys discussed the “Red Hot” Houston Texans heading into Gillette Stadium. Unlike the unanimous dread seen on other networks, the Pat McAfee Show Divisional Round picks for this game focused on C.J. Stroud’s incredible momentum following a 30-6 rout of the Steelers. Boston Connor, despite his local ties, admitted that the Texans’ “Dark Side” defense is a terrifying matchup for rookie Drake Maye, leading several members of the crew to officially put the Patriots on “Upset Alert” for the Sunday afternoon tilt.
2026 Divisional Round: Matchups and Odds
| Matchup | Venue | Crew Lean | Betting Line |
| Bills at Broncos | Empower Field | Broncos | DEN -3.5 |
| 49ers at Seahawks | Lumen Field | Seahawks | SEA -7.0 |
| Texans at Patriots | Gillette Stadium | Upset Alert | NE -3.5 |
| Rams at Bears | Soldier Field | Rams | LAR -3.5 |
Los Angeles Rams at Chicago Bears: Primetime Drama
Closing out the Divisional slate, the crew analyzed the primetime matchup between the Los Angeles Rams and the Chicago Bears at a freezing Soldier Field. In the final round of Pat McAfee Show Divisional Round picks, Darius Butler pointed to the “Stafford factor,” noting that Matthew Stafford’s veteran experience in cold-weather environments gives the Rams a distinct edge over a young Bears squad. While Chicago is riding high after a historic fourth-quarter comeback against the Packers, the McAfee crew largely sided with the Rams’ high-octane offense to silence the “Monsters of the Midway.”
The “Toxic Table” Lock of the Week
Every week, the show crowns one specific prediction as the “unshakable truth,” and for this round, the lock centered on the defensive trenches. As part of the Pat McAfee Show Divisional Round picks, the crew unanimously agreed that the Seattle Seahawks would record at least four sacks against the 49ers’ patchwork offensive line. This “Lock of the Week” reflects the crew’s belief that Seattle’s home-field advantage and healthy defensive front will be the deciding factor in the most lopsided spread of the weekend.
Final Thoughts: A Weekend of Chaos
As the show wrapped up, Pat reminded the “McAfee Mafia” that in the NFL, the only thing you can expect is the unexpected. The Pat McAfee Show Divisional Round picks serve as a roadmap for the weekend, but as the crew noted, the “playoff itch” can turn any favorite into a victim by Sunday night. Whether it’s Drake Maye proving the doubters wrong or Sam Darnold leading a Seahawks resurgence, the Divisional Round is poised to deliver the “absolute cinema” that football fans have been craving all season.
The road to Super Bowl LX is narrowing, and the stakes have never been higher for the remaining eight teams. Stay tuned to the show throughout the weekend for live reactions and the inevitable “I told you so” segments on Monday morning. One thing is certain: with the Pat McAfee Show Divisional Round picks in the books, the countdown to kickoff has officially reached a fever pitch.
