by NFL Week 10 Preview brings football fans a thrilling weekend packed with high-stakes matchups and playoff-defining moments. As the 2025 NFL season enters its second half, every snap matters with postseason hopes on the line. The NFC West remains a heated three-team race, while the AFC East and South feature battles that could reshape the standings. From the international showdown in Germany to a primetime clash under the lights on Sunday night, Week 10 promises nonstop excitement.
This detailed breakdown covers the key games, injury updates, and expert predictions to help fans stay ahead of the action. Whether you’re tracking fantasy performances or playoff scenarios, this NFL Week 10 Preview has you fully covered.
⚔️ NFC Showdowns: Defining the Conference Hierarchy
The NFC is arguably the more compelling conference this week, headlined by two monumental divisional matchups. The biggest must-watch game of the NFL Week 10 Preview is the clash between the Los Angeles Rams (6-2) and the San Francisco 49ers (6-3). The Rams, led by the MVP-caliber play of quarterback Matthew Stafford (who boasts 21 TDs and just 2 INTs), are seeking revenge after a Week 5 overtime loss to the 49ers.
A Rams win would effectively secure the season tiebreaker and give them a commanding lead in the NFC West. Simultaneously, the Seattle Seahawks (6-2) host the Arizona Cardinals (3-5) in a critical game that could either propel Seattle into sole division lead or keep Arizona’s faint hopes alive. The outcome of both NFC West contests will be instrumental in shaping the seeding for the entire conference.
🐻 Rookie vs. Veteran: The Intriguing Mid-Major Matchups
Beyond the divisional battles, a number of other games feature fascinating subplots. The Chicago Bears (5-3) host the New York Giants (2-7) in a showdown that pits two young, dynamic quarterbacks against each other: the Bears’ Caleb Williams and the Giants’ rookie sensation Jaxson Dart. This game highlights a trap opportunity for Chicago, which is trying to maintain its surprising winning streak against a Giants team finding its rhythm with a playmaking rookie QB.
Meanwhile, the Miami Dolphins (5-3) travel to face the Buffalo Bills (6-2) in a pivotal AFC East rematch. The Bills need a win to keep pace with the division-leading Patriots, making this NFL Week 10 Preview matchup a test of which AFC powerhouse can overcome their recent struggles and secure a crucial divisional victory.
🇩🇪 International Kickoff: Colts at Falcons Prediction
The action starts bright and early with the Indianapolis Colts (7-2) facing the Atlanta Falcons (3-5) in Frankfurt, Germany. The Colts, featuring their newly acquired All-Pro cornerback Sauce Gardner, are heavily favored and predicted to cruise in this contest. Our NFL Week 10 Preview prediction sees the Colts’ No. 1 scoring offense overpowering a Falcons team that is struggling for offensive consistency. Look for Indianapolis to rebound strongly from their turnover-heavy performance last week, setting the tone for the rest of the Sunday slate. The final prediction: Colts 31, Falcons 15.
🌙 Sunday Night Football Spotlight
Rounding out our NFL Week 10 Preview is the Sunday Night Football battle between the Los Angeles Chargers (6-3) and the Pittsburgh Steelers (5-3). This game presents a high-stakes challenge for the Chargers, whose offense, led by Justin Herbert, must contend with a ferocious Steelers pass rush while missing two key starting tackles. With the Chargers fighting for a Wild Card spot in the AFC and Pittsburgh leading the AFC North, this game will likely be a low-scoring, defensive affair. Prediction: Steelers 23, Chargers 19.
