The San Francisco 49ers’ road trip to face the Tampa Bay Buccaneers in Week 6 has been overshadowed by a significant quarterback crisis. Starting quarterback Brock Purdy has officially been ruled out for the contest, missing his fourth game this season due to his lingering Brock Purdy toe injury. To complicate matters, veteran backup Mac Jones is listed as questionable, battling both knee and oblique issues. This double injury concern, stemming from the persistent issue of the Brock Purdy toe injury, puts a tremendous amount of pressure on the 49ers’ offense as they head into a pivotal NFC showdown.
The Lingering Brock Purdy Toe Injury
Quarterback Brock Purdy’s status for Week 6 was determined after he failed to participate in practice throughout the week, a direct result of his problematic Brock Purdy toe injury. The issue first surfaced in the season opener, causing him to miss Week 2 and 3, and was then aggravated in Week 4 against the Jaguars. Head coach Kyle Shanahan confirmed that while there are no plans to place Purdy on Injured Reserve—which would require a minimum four-game absence—the team is prioritizing his long-term health over rushing him back. The re-aggravation of the Brock Purdy toe injury suggests a cautious approach is necessary, making his week-to-week status a point of major concern for the 49ers faithful.
Mac Jones’ Questionable Status and Expected Start
With Brock Purdy ruled out due to the Brock Purdy toe injury, the starting nod is expected to go to Mac Jones, despite his questionable tag. Jones is dealing with a knee issue and a new oblique injury suffered during the Week 5 overtime victory against the Rams. While Jones was limited in practice, the general consensus is that he will try to power through the pain and suit up against the Buccaneers, a team also battling its own injury issues. The 49ers’ decision to keep the roster spot for a third quarterback, Adrian Martinez, open is a clear indicator of the uncertainty surrounding not only the Brock Purdy toe injury but also Mac Jones’ ability to finish the game.
The Impact on the 49ers’ Game Plan
The absence of Brock Purdy, caused by the Brock Purdy toe injury, is set to significantly shape Kyle Shanahan’s offensive strategy for San Francisco. With Purdy sidelined, Mac Jones assumes the starting role, but his own injury concerns, coupled with potentially limited practice reps, may restrict his effectiveness. Despite going 3-0 this season while throwing for over 900 yards and six touchdowns, Jones will face added pressure to protect the football and make conservative decisions under center.

As a result, the 49ers are likely to lean heavily on star running back Christian McCaffrey to establish the ground game, control the clock, and ease the burden on the quarterback. The Brock Purdy toe injury effectively forces a more cautious, run-oriented approach, which minimizes risk but limits vertical passing opportunities and reduces offensive versatility. This strategy will be crucial against Tampa Bay’s formidable defensive front.
Receiver Woes Compound the Quarterback Problem
San Francisco’s offensive struggles go far beyond the Brock Purdy toe injury and Mac Jones’ questionable status, creating a precarious situation heading into Week 6 against the Buccaneers. The 49ers’ receiving corps has been significantly weakened, with rookie Ricky Pearsall ruled out due to a knee injury and veteran Jauan Jennings listed as questionable with ankle and rib concerns. These absences further complicate an already limited quarterback situation, making it difficult for Purdy or Jones to find reliable targets against Tampa Bay’s aggressive secondary.
With key receivers sidelined, the 49ers must rely heavily on depth players like Kendrick Bourne and tight end Jake Tonges to step up in critical moments. Offensive coordinator Mike McDaniel will likely have to adjust the game plan, emphasizing short passes, screens, and creative play-calling to mitigate the impact of these injuries. The ripple effect of the Brock Purdy toe injury underscores just how fragile San Francisco’s offense has become, as the team navigates a challenging matchup with limited weapons at their disposal.